Plastic model of the urokinase molecule
Mature urokinase consists of two polypeptide chains bound together with disulphide bonds. The protein consists of 3 different domains, a protease domain on one chain, and a kringle and EGF-like domain on the other chain. The kringle and EGF-like domains are needed for the interaction of the protein with blood-clotting factors and the release of the protein from the cell, respectively . Interestingly, the expression level of urokinase appears to correlate with the process of tumor expansion . The high activity of the urokinase enzyme is considered to lead to degradation of the extracellular matrix and the formation of metastases , which suggests that urokinase could be a potential target for cancer therapy .
- Ivan Konstantinov
- Artem Sokolov
Date: Dec 19, 2011
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